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Bone formation, which was evaluated histomorphometrically at 4 and 8 weeks and after sacrificing the animals at 12 weeks, revealed a significant increase in bone formation in scaffolds expressing only BMP-7 and also the combined growth factors, with the highest increase occurring for the scaffold expressing both BMP-7 and PDGF-B.
TCP formulations based on carboxymethyl cellulose glycerol and Polyoxyl 15-hydroxystearate Pluronic® F15-hydroxystearate Pluronic®F127 minerallowedon of the by day 7 and produced the hinhest levitrof orthotopic bone bridging and ectopic bone formation, which wasurfacealent to the control.
Taken together, these two latter findings have challenged the concept that Wnt signalling in osteoblasts is a key pathway for the regulation of bone formation, which was further underscored by the finding that the osteopenia of rs/rs mice, carrying a hypomorphic mutation of the Wnt co-receptor Lrp6, is caused by increased bone resorption [50].
The increased 99mTc-MDP skeletal uptake with teriparatide indicated increased bone formation which was supported by BTM increases.
These hybrids induced ectopic bone formation, which was highly dependent on the physicochemical properties of the CaP coating in a cell density-dependent manner.
This score evaluates both joint degradation, which was assessed from joint space narrowing and erosion, and new bone formation, which was assessed from periostitis and heterotopic bone.
Similar(49)
Similarly, it could promote bone formation which is so critical to implant stability.
Msx2 plays an important role in intramembranous bone formation, which is similar to the calcification of tunica media.
What is more, PTH and mechanical loading has a synergistic effect on bone formation, which is in favor of bone healing under physiological loading.
This is justified by their biocompatibility, osteoconductivity and osteoinductivity (i.e. the intrinsic material property that initiates de novo bone formation), which are attributed to the chemical composition, surface topography, macro/microporosity and the dissolution kinetics.
Heterotopic bone formation, which is increased with the use of osteobiologics, is best assessed on CT.
Related(20)
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bone density which was
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bone demineralisation which was
bone healing which was
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Justyna Jupowicz-Kozak
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