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In addition, markers of bone resorption and cartilage destruction were increased in arthritic mice, whereas markers of bone formation were increased in ovariectomized mice.
Biochemical markers of bone formation were increased with teriparatide treatment compared with placebo, and BMD and markers of bone formation did not substantially decrease for up to 1 year after discontinuation of teriparatide therapy (Cosman et al 2001).
Similarly, serum levels of P1NP, a marker of bone formation, were increased to a greater extent in the mutant mice relative to controls, while the levels of C-terminal telopeptide, a marker of bone resorption, were increased to a similar degree.
On the other hand, serum osteocalcin and bone-specific alkaline phosphatase, reflecting bone formation, were increased to a less degree compared to the increase of urinary pyridinoline cross-links, suggesting the imbalance between bone formation and resorption with subsequent bone loss in hyperthyroidism [ 2, 14].
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When rhBMP-2 was used to repair bone defects that remain after cyst enucleation, new bone formation was increased.
Bone formation was increased in a time-dependent manner and could be detected through the 3D images.
Dynamic histomorphometry indicated that bone formation was increased by PTH at both cortical and trabecular surfaces, whereas PRO increased osteoblast number and surface on trabecular surfaces.
At three weeks, the amount of bone formation was increased till about 10% for the titanium group and 18% for the ceramic group.
Quantification of the Ca-P cement implants showed that bone formation was increased significantly by administration of rhBMP-2 (10 weeks pore fill: 53.0±5.4%), and also reached a reasonable amount without rhBMP-2 (43.1±10.4%).
In addition, bone formation was increased in the TM injected CatnbEx3/+; Col2a1-CreER embryos indicated by von Kossa staining (Fig. 4A), suggesting that Wnt/ β-catenin signaling in chondrocytes may also promote bone formation in the perichondrium non-cell autonomously.
21 Bone formation was increased and bone resorption was decreased in the AnTT-treated group in that study, 21 whereas only bone formation was increased in the present study.
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