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To monitor the bone formation over time, fluorochrome markers were administered at 3, 5 and 7 weeks and the animals were sacrificed at 9 weeks after implantation.
For qualitative evaluation of bone formation over time, analysis with fluorochromes was performed with unstained sections.
Further, the findings suggest no acceleration of new bone formation over time in patients treated with golimumab for 4 years.
The radiographic progression rate remained stable at years 2 and 4, suggesting no acceleration of new bone formation over time.
8 At the same time, these findings do not support the hypothesis that blocking TNF may have stimulatory effects on new bone formation over time.
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Little is known about the distribution of new bone formation over prosthetic surfaces and about the intensity over time of bone on-growth in the clinical situation.
However, we observed bridging bone formation over the grafted bone between both ends of the host bones as well as de novo formed bone in the junction.
Although remodeling of the bone graft was not observed until 12 weeks, we observed bridging bone formation over the grafted bone between both ends of the autogenous bone, resulting in stability between the grafted bone and host bones.
We monitored bone formation at 7 time points over 35 weeks using time-lapsed micro-computed tomography (CT) imaging.
Immune system activity mounts and leads to progressive inflammation and scar tissue formation over time.
A useful mathematical model needs to explain the time course of product formation over time.
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