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"An indirect role of touch or proprioception in bone formation is an intriguing and exciting possibility".
In men, where decreased bone formation is an important etiological factor, an anabolic treatment seems a logical approach.
Bone formation is an intricate and ordered cascade of synthesis of matrix proteins and calcium phosphate in a continuously renewed biological environment and regulated by a cluster of growth factors [ 50].
Serum levels of BSAP remained stable for the first 2 weeks and then decreased in a dose-dependent manner, suggesting that the effect on bone formation is an indirect effect.
Although the specific molecular mechanism by which sclerostin inhibits bone formation is an area of continuing investigation, basic science and translational studies have demonstrated that sclerostin can bind to BMPs and Wnt co-receptors (LRP 5 and 6) and inhibit BMP-mediated bone formation as well as the canonical Wnt signaling pathway [ 75].
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The design of synthetic bone grafts to foster bone formation is a challenge in regenerative medicine.
Bone formation is a complex process that requires concerted function of multiple growth factors.
In vivo, bone formation is a complex, tightly regulated process, influenced by multiple biochemical and physical factors.
While ectopic bone formation is a standard activity of human BMSC on calcium phosphate ceramics, the bone formation capacity of human ATSC has so far been unclear.
The combination of potent osteoinductive growth factor, functional osteoblastic cells, and osteoconductive materials to induce bone formation is a well-established concept in bone tissue engineering.
In the meantime, evidences indicate that bone formation is a complex cascade of events, in which time-dependent expression of multiple growth factors is involved.
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bone formation becomes an
bone tissue is an
bone density is an
bone size is an
bone remodeling is an
bone formation has an
bone mass is an
bone allograft is an
bone grafting is an
bone structure is an
bone disease is an
bone erosion is an
bone resorption is an
bone ductility is an
bone defect is an
bone remodelling is an
bone histomorphometry is an
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