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However, in continuity with the endochondral bone front, a small zone of direct bone formation is also recognized.
Hypertrophic differentiation of chondrocytes, as well as bone formation, is also regulated by the Wnt/β-catenin pathway [ 101, 102].
Decompensated joint remodeling with florid new bone formation is also a feature of advanced OA, and generalized nodal OA represents a striking example of this bone-forming phenotype.
The shape of periosteal bone formation is also very useful; perpendicular, it almost always indicates malignancy (in infection, enzymes make the periosteum disappear).
The importance of caspases in bone formation is also supported by studies where overexpression of Bcl-2 was shown to result in the inhibition of osteoblast differentiation.
15, 16 Bone formation is also affected by estrogen deficiency with a reduction in the life span of osteoblast, thereby aggravating the negative bone balance.
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Twelve weeks after transplantation, the defects were repaired with hyaline cartilage-like tissue densely stained by Safranin O. Well-organized subonendral bone formation was also observed.
Histological assessment of the quality of bone formation was also carried out with bone cores obtained at the implant placement re-entry in one patient.
In previous studies that histomorphometrically observed the effects of autogenous tooth bones in comparison with synthetic bones as a control group in existing lower jaw defects of minipigs, new bone formation was also more excellent in the experimental group [15].
An additional endosteal bone formation was also noted but was more expressed in groups 3 and 4. Open image in new window Fig. 3 Osteointegration 1 month after intramedullary wires introduction: a, e group 1; b, f group 2; c, g group 3; d, h group 4. Upper row histotopographic sections.
Bone formation was also not affected by the intervention.
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