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Decellularized bone has been widely used as a scaffold for bone formation, due to its similarity to the native bone matrix and excellent osteoinductive and biomechanical properties.
In contrast, porous β-CS displayed poor new bone formation due to its rapid degradation, while porous β-TCP showed moderate bone regeneration starting on the surface of the implants, due to a lack of osteostimulation.
We conclude that Wwox KO mice have reduced bone formation due to a bone mineralization defect.
These observations strongly suggest that increased NEFA in serum from rats made obese by HFD-feeding impaired bone formation due to stimulation of bone marrow adipogenesis.
Thus, mice with PTHrP haploinsufficiency, or with deletion of the PTHrP gene specifically from osteoblasts, exhibit reduced bone formation due to increased osteoblast apoptosis.
Von Kossa staining showing aberrant bone formation due to bone metastasis of murine osteosarcoma LM8 cells.
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In summary, radiation-induced death of marrow cells is associated with 1) a transient increase in bone formation due, at least in part, to activation of bone lining cells, and 2) an increase in bone resorption due to increased osteoclast perimeter.
In the human body, these materials help inorganic bone structure formation due to a combination of the particular ratio of elements such as silicon (Si), calcium (Ca), sodium (Na) and phosphorus (P), and the doping of strontium (Sr) into the scaffold structure increases their bioactive behaviour.
Here, we used a human-in-mice model to study bone metastasis formation due to primary breast CSCs-like colonisation.
Its deficiency may lead to decreased bone mass by increased osteoclast formation due to increased MMA and Hcy levels (Vaes et al. 2010).
Thus, these results indicate that the decreased bone mass in Cthrc1-null mice is due to the suppression of osteoblastic bone formation, not due to an acceleration of osteoclastic bone resorption.
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bone resorption due to
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bone loss due to
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bone quality due to
bone malocclusion due to
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