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Furthermore, simultaneous administration of BMP-2 and 26SCS in vivo dose-dependently induced larger amounts of ectopic bone formation compared with BMP-2 alone.
When evaluated for in-vivo osteogenic activity in female Sprague-Dawley rats, BFC 20 increased bone mineral density and new bone formation, compared with control at 1.0 and 10.0 mg/kg/body weight by oral gavage for 30 days.
Histomorphometric evaluation showed that neither seeding human trabecular bone cells nor the culturing technique increased the amount of early bone formation compared with the level provided by osteoconductive bone ingrowth from the defect edges.
In this study, HA+rhBMP-2 showed relatively good bone formation compared with ABB.
Furthermore, when cultured under osteogenic inductive conditions on BioCoat™ Osteologic™ Discs, MSC exhibited a different pattern of bone formation compared with LL-37-differentiated monocytes as indicated by using SEM (Figure S4).
The result is a negative net balance of bone formation compared with resorption and progressive local bone erosions.
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According to a study by Hwang, the use of rhBMP-2 with ACS could result in accelerated bone formation compared to conventional bone grafting in postoperative bone defects [17].
Glass foams both with and without PRP showed an increase of bone thickness and histological bone formation compared to controls (no biomaterial).
The study of Laurencin (Attawin et al. 1995; Laurencin et al. 1996; Devin et al. 1996) demonstrated that porous scaffolds made from a PLGA/HA composite enhanced cell proliferation and differentiation, as well as bone mineral formation, compared with the PLGA group.
The MSC-CM group showed increased bone and blood vessel formation compared with the other groups (c, g).
In summary, greater and earlier increases in bone formation markers compared with bone resorption markers after teriparatide therapy suggest that bone gain initially results from modeling-based bone formation without prior bone resorption.
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