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Bone formation associated with each implant design was delineated through the administration of fluorescent vital dyes at three time points following their implantation into New Zealand white rabbits.
Indeed, it has been shown previously by our group and others that intramembranous bone formation associated with implant fixation is enhanced following local delivery of TGF-β[11], [57] [59].
Although somewhat more subtle, PTHrP also influences intramembranous ossification as well as bone formation associated with skeletal modeling in postnatal mice.
Therefore, it is tempting to speculate that the tendency toward excess bone formation associated with this triad contributes to the pathogenesis of certain subtypes of OA.
Widening of the femoral neck is driven by periosteal bone formation associated with compensatory endosteal resorption [42] and is associated with markers of sex hormone deficiency [43].
There was no appositional bone formation associated with granulation tissue around dead bone in keeping with the early stages of ANFH.
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SCW-injected tarsal joints had significant injury, localized primarily to the tibio-tarsal and proximal intertarsal joints and associated tibial and tarsal bones, characterized by slight inflammation and slight to moderate pannus formation (associated with overt bone loss).
One hypothesis is that the subchondral bone remodeling observed in osteoarthritis is different from that in osteoporosis [ 69, 70]: increased bone mineral density (i.e., increased bone formation) is associated with subchondral bone sclerosis, while decreased bone mineral density (i.e., increased resorption) is associated with subchondral bone osteopenia.
Bone resorption and bone formation were associated with a significant increase in BLLs among pre-and postmenopausal women.
In this study, we demonstrated that PTH is capable of increasing bone mass in myelomatous bones in vivo and that the increased bone formation is associated with a concomitant reduction in growth of the Hg myeloma cell line and primary myeloma cells from certain patients.
During puberty, in both humans and mice, linear growth and bone formation are associated with a rise in serum and skeletal IGF-1.
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