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The increased protein levels directly influenced bone formation around the fractures, leading to quicker, more effective healing.
Previous studies have shown that increasing surface roughness of metallic orthopaedic and dental implants improved bone formation around the implant.
Implantation of bone morphogenetic protein-2 (BMP-2 -loaded BMP-2 -loadedked alginate hydrogels induced moderate BMP-2 -loadedn around the imphotocrosslinked
The pullout force of the stainless steel screws was measured after 4 or 8 weeks, and µCT was used to assess bone formation around the PMMA screws.
Histological analysis revealed similar bone formation around the periphery of the coated and uncoated implants, but bone ingrowth is better within the Ta-coated scaffolds.
However, during bar removal, intense bone formation around the pectus bar and bar stabilizer makes it difficult to detach them from one another.
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Recently, pamidronic acid, a nitrogen-containing bisphosphonate, was reported to conjugate the titanium surface and stimulate new bone formations around the implant both in vitro and in vivo, which contribute to the success of the implant technology [22, 23].
Preliminary results demonstrate de novo bone formation around and inside the implant, vascularization around the implant, as well as the absence of a cytotoxic response.
The 3 mm passages showed very new bone formation around and along the scaffold, whereas it was clearly reduced in the without passages in nonstained images and 4(d)).
The results showed the simvastatin-HA coating improved the bone-implant contact and new bone formation around implant in the osteoporotic rats.
Notably, the interconnected mineralized tissue of MSCs groups at Week 12 demonstrated a shape similar to the screw-like scaffold (Fig. 11F); this outcome demonstrates that a 3D-printed screw-like scaffold can match the speed of new bone formation around a tendon graft and minimize the effect of slow-degrading PLA impeding new bone growth.
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