McElveen et al. [34] conducted a total 6 temporal bone experiments to study the effect of mastoid cavity modification on middle ear sound transmission.
The characteristics of this modified prosthesis were examined in temporal bone experiments and compared to the standard titanium total ossicular reconstruction prosthesis.
It appeared that the results from the temporal bone experiments and the FE-predicted results match, namely that blocking the aditus improves middle ear sound transmission in the 1500 to 2500 Hz range and decreases displacement in the low frequencies below 1000 Hz when compared with the normal ear.
These parameters were then checked in the validation process by comparing the RW membrane displacement amplitudes (Arw) derived from the FE model with the experimental data obtained from temporal bone experiments for the pre-stapedotomy state.
Not all of the relevant values are available in humans, so these either are borrowed from animal studies, are experimentally measured in vitro (usually by human temporal bone experiments), or have to be estimated through the comparison of model results with experimental studies.
"I realized that there was a close-to-the-bone experiment I could conduct to test whether going gray would be a detriment to romance for a woman my age.
MGS designed the experiments, performed the acridine orange analyses, the influx experiments, the bone resorption experiments, and drafted the manuscript.
Bone milling experiment video is shown as additional material.
This is one of the most delicate steps in the procedure; in case of failure (drilling though the skull bone), the experiment should be discontinued.
Groups were exposed to 0, 55, or 230 ppm Pb (in the form of Pb acetate) in drinking water for 6 weeks before initiation of the ectopic bone formation experiment.
In the present rat bone chamber experiment, BMP-7 sped up the ingrowth and the remodeling front advanced deeper into the graft than it would have without BMP-7.
