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Although the pathology itself can be well estimated on otoscopic examination, further questions concerning the extent of the disease, exact location, structures involved and possible bone erosion, will be addressed in detail only with CT and/or MRI.
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"The bones will be disturbed.
Conclusion: Bone erosion can be related to AFR.
Certain drugs can suppress inflammation effectively, but fail to protect against bone erosion, whereas under other conditions, bone erosion can be halted, but inflammation may continue unabated.
For the imaging subgroup, endpoints relating to inflammation (ultrasound synovitis, MRI inflammation) and damage (bone erosion or damage on ultrasound or MRI) will be measured at baseline and at 48 weeks.
As early cortical bone erosion is not well demonstrated on MRI, CT is indicated when bone involvement is clinically suspected.
Measurements of bone erosion volumes were obtained using OsiriX medical imaging software.
Such bone erosions may be mediated via anti-CII antibody-dependent C3 recruitment to the cartilage surface, which will initiate an immunological attack, eventually leading to bone destruction [ 39].
In practice, MRI bone erosions may be associated with an extensive halo of bone oedema.
However, bone erosion is partly dependent on IL-1 and cartilage erosion is completely dependent on it [ 51].
First, there will be no erosion.
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