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Subsequent histological analysis of the joints showed a normal synovial membrane with only occasional modest cellular inflammatory infiltration but no pannus formation or cartilage and bone erosion (data not shown).
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Furthermore, BME and bone erosion data were determined as averaged values derived from the synovectomised area.
As already stated, an early MRI bone erosion is not identical to mature radiographic erosion.
As early cortical bone erosion is not well demonstrated on MRI, CT is indicated when bone involvement is clinically suspected.
Bone erosion is not a purely resorptive process, but rather harbors complex interactions of bone resorption and formation throughout the entire cortical bone.
Indeed, OPG blocked bone erosion but did not affect synovial inflammation.
The effect of golimumab on bone erosions could not be determined by semi-quantitative scoring in these RA patients with minimal progression of bone erosions.
In contrast, OPG or anti-TNF alone led to arrest of bone erosions but did not achieve repair.
In contrast, OPG and anti-TNF alone led to arrest of bone erosions but did not achieve repair.
Analysis of osteoclasts and osteoblasts within the remaining bone erosions not only showed the anticipated dramatic reduction of osteoclasts in bone erosions (0.6 ± 0.4 osteoclasts per mm, -96%), but also a complete absence of osteoblasts (Table 1).
In arthritic animals, the histopathological abnormalities (cellular infiltration, synovitis, pannus formation, and cartilage and bone erosions) were similar to those (data not shown) described earlier in numerous papers [ 7- 9, 20, 28], and there were no differences in the histopathology when peripheral joints of any subcolonies with the same clinical scores [ 20] were compared (data not shown).
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