The results indicate that, compared with placebo, the 180 mg group exhibited significantly less progression of bone erosions compared with placebo (P < 0.019).
In addition, evidences reported that EPC counts were restored by anti-TNF α therapy in RA patients, and interestingly, the restoration of EPC counts seems to be attenuated in patients with a higher bone erosion score compared with those with a lower bone erosion score, despite a similar improvement in disease activity.
Administration of PIP-18 at doses of 30 mg/kg three times per week for five weeks in Tg197 mice resulted in a significant reduction (** P < 0.01) in all three analytical histopathologic scores (synovitis, cartilage destruction and bone erosion) as compared with those of untreated Tg197 mice, which all developed synovitis with severe articular cartilage degradation and bone erosions.
When we observed the three-dimensional μCT reconstruction images of femurs, tibiae, knee joints, and ankle joints, the CIA-vehicle group showed a reduction of the radio-opaque area and bone erosion surface compared with the Normal-vehicle group (Fig. 3a), confirming the validity of the model.
However, PMR-associated hand disease has a similar degree of MRI bone erosion and bone oedema compared with early RA [ 31].
However, in the saline-treated C57BL/6 and u-PA-/ knee joints, cellular infiltration and bone erosions were increased compared with the respective untreated knee joints.
The result is a negative net balance of bone formation compared with resorption and progressive local bone erosions.
