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In the present study, TIEG1 is shown to act as a positive regulator of Runx2 expression in osteoblasts implying an additional role for this transcription factor in regulating osteoblastogenesis and bone development through the actions of Runx2.
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We tested the hypothesis that HFD-induced obesity may impair bone development through elevated FFA levels by increasing bone marrow adipogenesis at the expense of osteoblast differentiation.
PTHLH is a member of the parathyroid hormone family which regulates endochondral bone development through regulation of chondrocyte proliferation and differentiation during early bone growth [ 22].
The results of this study suggest that lead adversely influences bone development through disruption of mineralization during growth.
Zhu X, Wang F, Zhao Y et al: A gain-of-function mutation in Tnni2 impeded bone development through increasing Hif3a expression in DA2B mice.
Insulin exerts a profound effect on bone development through increased differentiation of osteoblasts and concurrent formation of adipocytes.
The incidence of leg pathologies in broiler chickens with a developmental origin may be decreased by stimulating embryonic bone development through lighting schedules during incubation, but this may depend on post hatch lighting conditions.
The most common form of osteochondrosis in dogs is called osteochondritis dissecans (OCD), which is a defect in bone development at the extremity of a bone.
Bone development continues throughout the life of an individual, through balanced processes of bone growth and bone remodeling.
These effects on bone development occurred through cross-talk between Pkd1 and Hh pathways at the level of Gli2 expression in bone and osteoblasts.
During endochondral bone development, invasion of the primary ossification center artery precedes bone formation [21].
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