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At the histologic level, various degrees of synovitis and bone destruction were observed (Fig. 3a, b).
Hyperplasia of the synovium, inflammatory infiltrates in the joint space, pannus formation, and cartilage and bone destruction were observed.
Massive cell infiltration, cartilage erosion, and bone destruction were observed in joints of vehicle-treated or celecoxib-treated mice but not in those of TFM-C-treated mice.
In some cases tumor was present outside the cortical shaft; no significant differences in bone destruction were observed between animals from either groups (Table 1).
Cell infiltration in the synovial tissues and radiographical bone destruction were observed in vehicle-treated CIA mice, and reduced significantly in the JWH133-treated mice.
In wild-type mice, only minor inflammatory changes and a smooth cartilage surface without significant cartilage or bone destruction were observed.
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In some instances, bone destruction was also observed in the carpal joints (Figure 2E), and in rare instances bone destruction was observed in the knees (data not shown).
However, in Ki26894-treated mice, serum levels of soluble IL-6 receptor remained low (Figure 7A) and only marginal bone destruction was observed on X-ray radiography (Figure 7B).
Similarly, the involved vertebral levels were instrumented one level above and one level below the involved vertebral levels if severe bone destruction was observed involving the infected vertebrae.
Histologic analysis showed that severe arthritis with high bone destruction was observed in the vehicle-treated group, which was inhibited by MTX (Table 4).
For the OSM + IL-1 combination (Fig. 1e,1f), pronounced bone destruction was observed with severe synovial hyperplasia and soft tissue inflammation.
More suggestions(17)
bone destruction were determined
bone destruction were aggravated
bone degradation were observed
bone tissue were observed
bone microarchitecture were observed
bone maturation were observed
bone mineralization were observed
bone destruction were graded
bone volume were observed
bone destruction were reduced
bone density were observed
bone marrow were observed
bone formation were observed
bone destruction were compared
bone erosion were observed
bone loss were observed
bone robustness were observed
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