Sentence examples for bone destruction through the from inspiring English sources
ABCC5 functions to promote osteolytic bone destruction through the recruitment and enhanced formation of osteoclasts.
These cancers cells secrete factors such as parathyroid hormone-related protein (PTHrP) which stimulate osteoclast-mediated bone destruction through the RANK/RANKL/OPG signaling pathway [ 22, 27].
Similarly, there are several ways in which T cells might be regulatory in an effector state like this: for example, they might control bone destruction through interaction with the osteoprotegrin system [ 23] or through the regulation of cytokines such as IFN-β, tumour necrosis factor-α or IL-4 [ 24- 26].
Therapy with both TNF antagonists and local corticosteroids modulates the RANKL/OPG system, inhibiting bone destruction through distinct mechanisms.
It typically acts as a decoy receptor that binds to RANKL and prevents its association with RANK with the net result of preventing excessive bone destruction through activation of osteoclasts[39].
These findings therefore suggest that in vivo blockade of endogenous IL-23 has an effect on preventing bone destruction through a decrease in inflammatory cytokines associated with bone destruction.
In collagen-induced and adjuvant arthritis models, intraperitoneal or intraarticular injection of IFNβ resulted in reduction of disease activity and inhibition of cartilage and bone destruction through a significant decrease of TNF and IL-6 expression and an enhancement of IL-10 responses at the site of inflammation [ 20, 38, 39].
By blocking TNFα, adalimumab can attenuate cartilage and bone destruction partially through the downregulation of matrix metalloproteinases [ 13].
Lymphoma usually causes permeative bone destruction and invades the skull base through the foramina[ 71, 72 ].
The bone destruction observed in the joints of patients with RA presents a challenging clinical problem.
