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We are still to determine the importance of the neutrophil in regulating the bone destruction that occurs in RA and other chronic inflammatory conditions.
S. aureus arthritis is a severe disease associated with significant bone destruction that occurs despite antibiotic treatment.
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This cumulative work supports the involvement of MIF in the cartilage damage and bone remodelling that is central to the progressive joint destruction that occurs in RA.
Periodontitis is a slowly progressing disease but the tissue destruction that occurs is largely irreversible.
The destruction that occurs when cheaters prosper is the opposite of "creative".
The excessive bone destruction that is characteristic of multiple myeloma is dependent on osteoclast stimulation.
In contrast, MOSJ-Dkk1 tumors were much larger and caused lytic bone destruction that was particularly evident in the fibulas.
Bone metastases in breast cancer patients are also associated with bone destruction that correlates with hypercalcaemia and fractures.
The pockets deepen as a result of the further destruction of fibres of the periodontal ligament (referred to as attachment loss; Fig. 1) and the resorption of the alveolar bone that occurs in parallel with the progressing attachment loss.
The malignant disorder, myeloma, is characterized by extensive bone destruction, which is manifested by a number of important clinical features including intractable bone pain, fractures that occur either spontaneously or following trivial injury, and hypercalcemia, which can be life-threatening.
In RA it has been postulated that bone destruction occurs as a direct consequence of inflammation.
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