Sentence examples for bone destruction compared with from inspiring English sources
They also had less cartilage and bone destruction compared with animals of the sham group, confirming the clinical scoring (figure 2D).
However, μCT analysis revealed that reduced ABCC5 expression in mouse-derived 4T1 cells resulted in significantly less (shRNA 1, 26% bone destruction; shRNA 2, 16% bone destruction) bone destruction compared with the scrambled controls (40% bone destruction).
Using intra-peritoneal injection of SFN, the authors demonstrated that this compound ameliorated the effects of CIA with lower degrees of inflammation, synovial hyperplasia, pannus formation, and bone destruction compared with vehicle alone [ 95].
The OVX group treated with DCA had an earlier onset of disease, more frequent and more severe arthritis, and more synovitis and bone destruction compared with the sham-operated group treated with DCA, which had intact estrogen production.
As shown in Figure 5A and 5B, arthritic joints treated using medium and high doses showed lower grades of inflammation, synovial membrane thickness, and cartilage and bone destruction compared to those with control protein treatment or treatment with a low dose of immunotoxin.
Induction of arthritis in WT mice led to severe local joint inflammation, characterized by pronounced cellular infiltration and osteoclast recruitment with associated bone destruction compared to PBS control knees (Figure 1A,B and 2A,B).
Risedronate, alone or in combination with docetaxel, prevented osteolytic bone destruction compared to control, whereas administration of docetaxel alone had no effect.
Consistent with the decreased clinical arthritis, MKK7 ASO suppressed synovial inflammation, bone erosions and cartilage destruction compared with control ASO (see Figure 3).
Further, the MMP13 /– mice showed a significant reduction in inflammation and in bone and cartilage destruction when compared with the control C57BL/6 mice on days 4 and 8 post serum transfer.
We have previously identified Cia5d as an arthritis severity locus and showed that DA.F344(Cia5d) rats congenic for this interval developed significantly milder arthritis, with nearly no pannus formation and neither bone nor cartilage destruction, as compared with highly susceptible DA rats [ 14].
Rats receiving T-614 at 5 mg/kg per day exhibited significantly less bone destruction (P < 0.05), as measured by total bone volume, compared with vehicle-treated arthritic controls.
