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Aggressive debridement creates segmental bone defects.
The regeneration of large bone defects remains clinically challenging.
Non-healing bone defects present tremendous socioeconomic costs.
Ten patients with 16 fixtures developed severe marginal bone defects.
Currently available therapies for segmental bone defects have some drawbacks.
Cartilage and bone defects represent common and severe clinical problems.
Particularly, complex bone defects are difficult to reconstruct accurately.
Natural healing in large bone defects often fails.
We are still far from routine filling in bone defects.
Repairing bone defects is a fairly common surgical procedure.
Aggressive debridement is followed by the creation of large bone defects.
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