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A periprosthetic infection with segmental bone defect is a surgical disaster.
Bone defect is a common clinical problem that deserves an optimal therapy.
A bone defect is a much different in vivo environment, however, which has both inflammation and bone turnover.
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A significant bone defect is an anatomical limitation that can be overcome using different surgical techniques, including vertically guided bone regeneration.
Repairing bone defects is a fairly common surgical procedure.
Regeneration of bone defects is a clinical challenge that usually necessitates bone grafting materials.
Management of segmental bone defects is a considerable challenge for orthopedic surgeons.
Treatment of critical-size bone defects is a major medical challenge since neither the bone tissue can regenerate nor current regenerative approaches are effective.
Repairing large bone defects is a major orthopaedic problem, with current treatments being constrained by the regenerative capacity of human tissue.
Treatment of bone defects is a continuous challenge in skeletal trauma and orthopaedic trauma surgery.
Nevertheless, the capacity of repairing bone defects is a key factor to assess the osteogenic ability in bone tissue engineering.
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