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Furthermore, in studies that blocked IL-17A or in IL-17R-/ mice reduced inflammation and bone damage was observed [ 61, 62].
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No increase in chromosome damage was observed in bone marrow cells, spermatogonia, and primary spermatocytes.
Obvious DNA damage was observed in bone marrow cells of mice exposed to arsenic (0.05 and 5 ppm) for 180 days (Singh et al. 2010).
Cytogenetic damage was observed in the rat bone marrow, especially at the high concentration of 5000 ppm.
From that perspective, no structural damage was observed, Mr. Peraza said.
Therefore, much damage was observed in the Kurayoshi area; however, the damage was not severe.
No severe damage was observed near the inundation limit.
Up to R = 1/30 rad, no appreciable damage was observed.
No major cell structural damage was observed.
Severe bone erosion and joint damage were observed in PBS- or Fc-injected mice (arrows), but mild to moderate erosion (arrowheads) and periarticular osteopenia (asterisks) were observed in the mice injected with VEGF-Trap or Tie2-Fc.
Similar patterns of trabecular bone damage were also observed in the proximal tibial region (data not shown).
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