Therefore, even in the presence of a minimal bone marrow contamination, it is likely that no tumour cell was missed owing to the different cell layer sedimented.
We can thus conclude that, although finding low ErbB2 levels does not exclude neoplastic bone marrow contamination, high levels of ErbB2 expression in aphereses might be evocative of micrometastasis.
Theoretically speaking bone marrow contamination can be better associated with systemic spread, rather than with locoregional failure; nevertheless both types of recurrence (intra-abdominal and haematogenous) are probably different steps of a unique and complex process and should therefore be somehow linked.
To ensure there was no contamination, bone material from inside the bone was removed by a dental pick while the surface of the bone was left intact.
Before taking a sample of compact bone tissue any contamination residing on the bone surface was removed mechanically in all but one case from each skeleton.
Alternatively, they might be incidental epibionts because the worms could not be cleanly separated from associated bone and sediment contamination.
Bacterial contamination of bone allograft is a significant complication of orthopedic surgery.
We tested the method in four El Sidrón Neandertal samples (two teeth and two bone fragments) with different contamination levels and taphonomic conditions, and we have been able to significantly increase the Neandertal yield from figures around 25.23% (5 69.6%) up to 90.18%75.3 100%0%75.3 100%
7. Monro JA, Leon R, Puri BK. "The risk of lead contamination in bone broth diets," Med Hypotheses.
However, the histological structure of the bone also correlates with contamination levels [36], and the cortical tissue in Myotragus limb bones is thinner than in other, larger extinct mammals, such as mammoths and Neanderthals.
