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Scientific evidence Level 2: In cemented prostheses, the use of antibiotic-loaded bone cement has a prophylactic effect on deep infections.
Antibiotic-loaded bone cement has a protective effect by release of the antibiotic from the surface.
Palacos bone cement has a very good track record, even with long follow-up, and we do cannot infer that Cemex is a better bone cement based on these measured differences, since they were too small to be clinically significant.
Unfortunately, bone cement has a surface quite suitable for colonization, and although antibiotic loading can reduce biofilm formation, organisms are still able to grow, for example, on gentamicin-loaded bone cements [ 33, 61].
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The biofilm on Palacos R-G bone cement had a high density of live bacteria compared with the low density or total absence of live bacteria on Copal bone cement.
In our earlier report, we proved that use of the bisphosphonate that was present in the bone cement had a positive effect on bone turnover by acting directly on some important markers in the rats' serum.
The bone cement had an average thickness of 2.34 mm (SD, 0.86 mm).
The FB surface facing the bone cement had an average roughness (Ra) of 0.51 1.39 µm and a 20-grit-blast dry aluminium oxide finish.
The MB surface facing the bone cement had an Ra of < 1µm and a 220-grit-blast dry aluminium oxide finish (Ra and finish values according to the manufacturer's information).
In fact, most commercial acrylic bone cements have an elastic modulus in the range of 1700 3700 MPa [ 9, 10], while the elastic modulus of vertebral trabecular bone is typically in the range of 10 750 MPa [ 11– 13], encompassing osteoporotic to healthy bone.
Acrylic bone cement has been an essential non-metallic implant used as fixing agent in the cemented total joint arthroplasty (THA).
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