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An important clinical outcome of vitamin D deficiency is osteomalacia, which has been previously reported in females of the Hazara Division, Pakistan [ 17] but due to the ethical concerns we were unable to access bone biopsy samples of participants in our study and correlate histological findings with vitamin D deficiency.
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Nine patients reportedly developed spontaneous nonspinal fractures after 1 to 8 years of alendronate therapy, and histomorphometric analysis of the bone biopsy samples revealed severe suppression of bone turnover.
Of note, speculation about contamination of bone biopsy samples from skin seems to be inconsistent after standard antiseptic procedures in the operation field.
Interestingly, one study found a higher rate of CoNS in the percutaneous bone biopsy samples than in the swab samples (25.6 % vs. 4.6 %; p < 0.001) [ 2].
Bone biopsy samples become widely used to monitor the effects on trabecular architecture and mineralization in clinical studies during the treatment of bone diseases.
Bone biopsy samples are becoming widely used to monitor the effects on trabecular architecture and mineralization in clinical studies during the treatment of bone diseases.
Alveolar cancellous bone biopsy samples were extracted during dental implant preparation for investigating microstructural changes due to menopause and relationships between these changes and bone turnover markers.
To maximize the number of biopsies and to limit drop outs, the protocol was designed so that we obtain a single bone biopsy at one year follow up, rather than obtaining repeat bone biopsy samples.
Remaining isolates were from bone biopsy samples (4%), pleural fluid (2%), pleural biopsy samples (2%), and stool samples (2%).
We regret that we could not use bone biopsy sample in case of osteomyelitis.
A bone biopsy sample revealed Enterococcus faecalis, Enterobacter cloacae, and C. tetani.
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