Of the 46 patients with positive bone scan, 19 patients had bone metastases confirmed by X-rays in 1 patient, CT scans in 6 patients (pelvic CT in 2 patients, brain CT in one patient, and chest CT in 3 patients), MRI scans in 6 patients, and positive bone biopsy in 6 patients, respectively.
D'Haese et al. [ 20] performed bone biopsy in 33 patients in the LC group and 30 patients in the CC group at the baseline and one year after treatment, respectively.
Malluche et al. [ 21] performed bone biopsy in 32 patients in the LC group and 33 patients in the CC group at the baseline and 1 and 2 years after treatment.
In a substudy of the HORIZON pivotal fracture trial (Recker et al 2008) 152 patients receiving intravenous zoledronic acid 5 mg once-yearly underwent bone biopsy in order to determine effects on bone remodelling and bone architecture.
FDG-PET/CT is the imaging modality of choice for staging and response assessment of FDG-avid lymphomas and obviates the need for pretreatment bone marrow biopsy in patients with Hodgkin lymphoma and most cases of diffuse large B-cell lymphoma [38].
Although bone biopsies are not routinely undertaken in all hemodialysis patients, we have, as part of a research project into bone histology in patients converting to alternate nightly haemodialysis, performed bone biopsies in a cohort of 26 patients [ 22].
Moreover, bone biopsies in lasofoxifene-treated subjects showed bone of normal quality.
Importantly, bone biopsies in lasofoxifene treated subjects showed bone of normal quality.
In this paper, we report two cases in which bone biopsies from patients under Bps showed unusual giant, multinucleated OC that were not associated with resorption activity.
