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The likelihood that a chemical could be sequestered in certain tissues (e.g., fat or bone), bind to plasma proteins, and so on is assessed similarly using physicochemical properties.
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Hypercalcaemia may be partially accounted for by the release of bone bound calcium from lytic deposits, and conversely in the sclerotic metastases of prostate cancer there is calcium 'bone hunger' for new bone formation, which may even lead to secondary hyperparathyroidism (Minisola et al, 1987).
The latest victim goes in, and the results of previous dissections sit outside the back door, buckets and drums filled with manatee bones bound for classroom displays.
For example, "the ones for osteoporosis go to the bone and bind there and stay," Dr. Reidenberg explained.
Cells in their ovaries lacked the receptors to which the bone hormone binds.
These results are microscopically and morphologically compared with soft-tissue extracts from vertebrate fossils from the Hell Creek Formation of southeastern Montana (Latest Maastrichtian) in order to investigate the potential role of microbial biofilms on the preservation of fossil bone and bound organic matter in a variety of taphonomic settings.
18 Like other bisphosphonates, Zol has a high affinity for mineralized bone and binds to the calcium phosphate bone mineral hydroxyapatite, 19 with preferential localization at sites of high bone turnover.
Cells isolated from RA bone marrow bound significantly more Ki-67 than cells isolated from OA bone marrow, indicating that RA cells proliferated more vigorously There were elevated levels of IL-15 in bone marrow plasma from RA in comparison with OA patients (1304.5 ± 956.3 pg/ml and 760 ± 238.7 pg/ml, respectively, P = 0.01).
Or in the words of Creedence Clearwater Revival, "Don't go round tonight, your bones are bound to break on a beach site.
We developed bisphosphonate-chemotherapeutic conjugates designed to bind bone and hydrolyze, releasing both compounds, thereby targeting both osteoclasts and tumor cells.
Then, they crush the foot further until the arch bone breaks and bind some more.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com