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However, there is little consensus about the optimal constitutive law to describe bone as a material.
Tissue engineering and regenerative medicine approaches strive to develop alternative strategies to regenerate deficient bone, but as yet such approaches have not successfully reproduced the exceptional properties of bone as a material.
By contrast, ex vivo protocols only assess bone as a material [ 8, 10].
The quality of bone, as a material, may have been underestimated in the understanding of the etiology and progression of disease (3).
Micro-cracks within bone as a material normally initiate a remodeling process that results in repair through secondary osteonal bone formation [ 37].
The "chemical" nature or quality of the newly synthesized bone as a material may be indistinguishable from the original bone tissue.
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Bone, both as a material and structural organ, is acutely responsive to changes in both the biological and mechanical environments.
So faced with the challenge of designing new materials for bone regeneration/replacement, this chapter underlines the study of bone as a composite material.
The aim of this study was to evaluate the effect of autogenous tooth bone as a graft material for regeneration of bone in vertical bony defects of the minipigs.
In this study, we investigate the efficacy of demineralized bone matrix (DBM) as a material for frontal sinus obliteration in a rabbit model.
If correct, this would explain why attempts to make marrow in Petri dishes have failed.To test their idea, Dr Kotov and his colleagues tried to replicate the interior of a bone using a material, known as a hydromel, that is similar in composition to a soft contact lens.
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