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Micro-CT analysis of the tibiae revealed that Hdac4−/− mice have significantly decreased cortical bone area compared with the wild type mice.
Those with cysts had less lateral tibial cartilage volume and greater tibial plateau bone area compared with those who did not have a cyst (Table 1).
Those who were obese (BMI ≥30 kg/m) also had greater medial tibial bone area compared with normal weight subjects [ 16].
Treatment with GM6001 at 100 μM did not change the extent of resorbed bone area compared with the area associated with vehicle-treated cells, which is in alignment with previously published data [ 13].
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The results demonstrated that the scaffolds with engineered macroscopic channels and a porosity gradient had higher percentages of new bone area, compared to scaffolds without engineered channels.
There is increased F-FLT uptake in the bone marrow areas compared with that in healthy control subjects and a significant expansion of the bone marrow compartment in patients with MDS (Fig. 4b).
Microporous HA scaffolds revealed four times more bone ingrowth and seven times higher bone contact area compared to the ZrO2 scaffolds.
-How do the damaged areas compare with the total area of the country?
In both newborn EGFR-null mice (Wang et al, 2004) and 4-week-old AREG-null mice (Qin et al, 2005), trabecular bone area was decreased compared with wild-type mice, indicating the imbalance of bone remodelling.
At 5 days after simvastatin injection, the expression of RANKL was depressed and there were fewer osteoclasts, while the new forming bone area was larger compared with the control group.
Consequently, a greater implant surface area is required to obtain a similar amount of bone-implant contact in soft bone compared with denser bone quality.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com