The rationale is that absorbed arsenic in the blood circulation can reach to the bone marrow and may affect the cell survival of MSCs.
In addition, cracks and voids could be also generated by micromovement between cement and prosthesis/bone or by wear, and may affect the mechanical properties.
For this reason there has been increasing interest in studying architectural parameters of bone, beyond bone density, which may affect bone strength.
Commercial bone substitutes significantly differ in terms of calcium concentration, particle size, and crystallinity from autogenous bone, which may affect their clinical applications and performance.
While OA is a joint disease characterized by degeneration of articular cartilage and bone remodeling that may affect different sites and involve peripheral or axial joints, OP is characterized by low bone mass, and microarchitectural deterioration of bony tissue, with a consequent increase in bone fragility and susceptibility to fractures.
The juxtacrine interaction of BMSCs and macrophages occurring in the bone marrow may affect the surrounding cells in the bone marrow environment by releasing vital signals.
The molecular structure, the dispersity of the contrast medium, or the distribution of pores introduced during the preparation of bone cements may affect their mechanical properties, and these complex factors make interpretation of the data and comparison between studies difficult.
Subchondral bone resorption may affect different articulations, most commonly the sacroiliac, sternoclavicular and acromioclavicular joints, intervertebral discs and the symphysis pubis.
Since vanadium compounds are accumulated in vivo in bone, they may affect bone turnover.
In addition, we determined how these rapid, zoledronic acid-induced, changes to the bone microenvironment may affect early colonisation of particular areas of bone by breast cancer cells.
