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The necessity of escaping predators and the handicap of a heavy digestive system have resulted in limb bone adaptations.
Future studies are warranted to elucidate the processes that mediate these effects and the factors responsible for discordant calvaria bone adaptations between STS-131 and Bion-M1 mice.
Genetic responsiveness (e.g. sex or strain of animals) or in-flight environmental conditions other than microgravity (e.g. pCO2 levels) may have elicited different bone adaptations in STS-131 and Bion-M1 mice.
Nevertheless, it is also possible that, in primary OA, a multitude of other bone adaptations which do not invoke a resorptive state are occurring.
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Bone functional bone adaptation [42] [46] is one of the cardinal principles in skeletal biology depicting a homeostatic feedback system evolved to maintain the skeletal integrity in different loading milieus through appropriate modifications in bone geometry and structure, and/or material properties - with or without changes in bone mass.
The size and sophistication of models has increased significantly since that paper and a range of techniques are available from predicting the initial mechanical environment through to advanced adaptive simulations including bone adaptation, tissue differentiation, damage accumulation and wear.
Taking into account previous studies showing a reduced bone adaptation response to mechanical loading in adulthood, these results suggest that the diminished adaptive response is in part due to a reduction in the strains induced within the bone.
The internal bone adaptation of the proximal femur is considered.
This cautions against simple interpretations of trabecular bone adaptation in the anthropoid femoral neck.
However, the bone adaptation response is significantly reduced with increasing age.
We investigated this hypothesis with an established computational bone adaptation model.
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