However, some fundamental rules and biochemical mechanisms have been established, based on engineering, organ physiology, and cell and molecular biology, that explain and account for the process of bone adaptation to the mechanical environment.
The 12-week HRLF rats had increased trabecular bone volume, compared to NC and increased trabecular numbers, compared to the other groups, changes indicative of bone adaptation to the task.
Bone functional bone adaptation [42] [46] is one of the cardinal principles in skeletal biology depicting a homeostatic feedback system evolved to maintain the skeletal integrity in different loading milieus through appropriate modifications in bone geometry and structure, and/or material properties - with or without changes in bone mass.
Ruimerman et al. [ 216] applied this model to simulate bone adaptation under the influence of changes in the load orientation.
This cautions against simple interpretations of trabecular bone adaptation in the anthropoid femoral neck.
The multi-criteria objective function takes into account the initial stability of the femoral stem and the effect of stress shielding on bone adaptation after the surgery.
To develop a model for early post-menopausal women and determine the effect of aging on cancellous bone adaptation in the adult mouse skeleton, in vivo tibial compression was applied to adult (26 week old) osteopenic female mice using loading parameters, peak applied load and peak diaphyseal strain magnitude, that were previously found to be osteogenic in young, growing (10 week old) mice.
This study simulated and compared the bone adaptation processes of two different structures: (1) femoral bone that has normal cortical bone shape and (2) perturbed femoral bone that has an artificial bone lump in the inferomedial cortex.
We therefore aimed to investigate if OA bone structural changes can result from mechanoregulated bone adaptation, independent of cartilage degeneration.
In the field of bone adaptation, it is believed that the morphology of bone is affected by its mechanical loads, and bone has self-optimizing capability; this phenomenon is well known as Wolff's law of the transformation of bone.
