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Another advantage of having a surface enriched in silica is the presence of surface silanol groups that can easily react with alcohols and silane coupling agents [126] to produce dispersions that are not only stable in nonaqueous solvents, but also provide the ideal anchorage for covalent bonding of specific ligands.
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Our docking results verified the validity of experiments and showed that the specific ligands could form hydrogen bonds with some of the conserved residues, such as Cys 60 and Gln 64 of Ac-ASP3.
The inability of a ligand to signal with a particular TAS2R16 variant implies that the associated mutated residue contributes to recognition of that specific ligand.
Ellington, A. D. & Szostak, J. W. In vitro selection of RNA molecules that bind specific ligands.
We review the bonding of these ligands with metals in these compounds.
For the RdeaH2 compounds (12) a similar synthesis was used, with the available ligands seemingly accommodating the reduced bonding of this ligand cf. teaH2−.
Bermudez, M. & Wolber, G. Structure versus function-The impact of computational methods on the discovery of specific GPCR-ligands.
Besides, the rotatable bonds of the ligands ranged widely from 0 to 22, with greater than 88.8% of the ligands possessing fewer than 15 such bonds.
The adhesion of a cell to a surface is mediated by reversible bonds between specific receptor-ligand molecules [18].
This again shows that the accurate and specific ligand binding could be hampered by the presence of Gd@C82(OH)22.
Specific ligand substitutions decrease the EC50 values for TAS2R16 activation.
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