When they are individually classified based on the nature of their disulfide bonding, domains II and IV differ in the number and subtype of laminin-like modules [ 12] (shown as differences in module shape in Figure 1a).
Additionally, BGIBMGA005615, BGIBMGA007766 type, BGIBMGA010285 type and BGIBMGA011199 type all have the conserved catalytic residues and/or cofactor bonding domains based on available crystal structure information of their bacterial homologs, except for BGIBMGA008215 whose substrate recognizing motifs were replaced (Additional file 6, Figure S3, S5, S6, S8 and S9) [ 47- 52].
These protein regions, such as the cystein-bond domain in the carboxyl terminus, are highly conserved and rich in cystein residues, enabling disulphide bridge formation and protein oligomerization, and increasing mucus viscosity [ 19– 24].
This coupling between elasticity modeling of interfacial traction/separation and stochastic events starts at the initial state when all bonds are closed and the process proceeds until all bonds within the adhesion domain become open.
Up to strains of 40%, the LC mesogens align with the strain field and the hard segments in hydrogen bonded domains align perpendicular to the field.
AMA1 consists of 3 disulphide bonded domains, D1, D3 and D3 [22].
61 The ARM5 comprises a single 'core alliance' domain consisting of items from the ARM bond, partnership and confidence domains.
Propensity to disulfide bond formation is suggested by the presence of a CysB CysG bond in domain I69 despite the unfavorable conditions used to produce and crystalize the recombinant I65 I70 fragment15.
Hydrogen bonds between domain 1 and domains 3 and 4 of Pvs25.
The aim of the paper is to show how to model complex systems in bond graph domain.
