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"A colleague suggested that photochemical processes might be able to bond tissue surfaces together without the collateral thermal damage accompanying laser welding of tissues," says Kochevar.
These findings could facilitate designing novel coated calcium phosphate surfaces that more rapidly bond tissue following implantation.
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Fibrin glue (FG) is used worldwide as a potent surgical tool, which establishes hemostasis in wounds and also bonds tissue.
However, as Ti6Al4V is not bioactive in its conventional form, hydroxyapatite (HAp) and tricalcium phosphate (TCP) have been widely used as coatings of metal prostheses due to their osteogenic properties and ability to form strong bonds with bone tissue.
In vitro bioactivity appraisement results show that apatite was formed on the coating surface after immersion in simulated body fluid (SBF) for 3 weeks, which indicates that the mesoporous film has the potential for chemical bonding with bone tissue after being implanted into an animal body.
Finally, mature regenerated bone tissue bonded with the TiO2/PEEK implant, indicating superior osseointegration.
From these mechanisms, the SBF test simulates only the chemical bond to tissues which could be predicted by their apatite-forming ability on samples surface [25].
In this work, poly N-isopropylacrylamide) (poly N-isopropylacrylamidechondroitin sulfate (CS) (PNIPAAm-g-CS) and blended wash aldehyde-modified CS to graftede an injectable polymer that can form covalent bonds with tissue upon chondroitin
This work is based on the hypothesis that the discharge of gelatin will enhance the biocompatibility of the material by covalently reacting with, or "end-capping", the aldehyde functionalities within the gel that did not participate in bonding with tissue upon contact.
FTIRI is sensitive to the vibration of dipole moments of chemical bonds in tissue.
This biocompatible adhesive provides tight bonding of tissue to reduce the dead space between tissue layers and minimizes shearing forces during the healing process.
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