At total conversion of CMA, the Co2Si@C nanocatalyst was chemoselective for the hydrogenation of polar CO bonds (selectivity to cinnamyl alcohol of ∼60%), whereas Ni2Si@C nanocatalyst was highly chemoselective for the hydrogenation of non-polar CC bonds (selectivity to hydrocinnamaldehyde of ∼90%).
In this capacity, the effects of reaction conditions, including temperature, base concentration, hydrogen pressure, catalyst amount and catalyst type, on the C C vs. C O bond cleavage selectivity of 2,4-pentanediol hydrogenolysis are investigated both experimentally and via simulation.
The high hydrogenation activity and CC bond hydrogenation selectivity was attributed to the 2D morphology of the support with an extremely high accessible surface for reactant access and for desorption of the intermediate products before secondary hydrogenation.
In the current work, the process of 2,4-PD hydrogenolysis is studied in a combined effort of experiments and computer simulation, to understand the mechanism and factors controlling the C C vs. C O bond cleavage selectivity of this process.
Their catalytic properties were superior to those of a commercial sulfided Co-Mo hydrotreatment catalyst, having higher activities and better C-N bond hydrogenolysis selectivities.
Comparison of HP-1 and -2 was used to determine the impact of the double bond on deacetylation selectivity among HDAC isoforms and the necessity of aldehyde formation for intracellular retention of deacetylated HP-1 (DHP-1).
The receptor 2 binds anions through hydrogen bonds with a selectivity of CH3CO−2 > H2PO−4 > C6H5CO−2 > HSO−4 > ClO−4 > NO−3.
On the basis of equilibrium studies in aprotic solvents (mainly MeCN and DMSO), it is shown that the energy of the hydrogen bonding interaction and selectivity are solely related to the acidic tendencies of the receptor and to the basic properties of the anion.
Notably, perfluoroalkyloxaziridines hydroxylate certain C-H bonds with high selectivity.
Using the atomic structure of Kv1.2/2.1 as the roadmap, Pless et al. ask a series of specific questions regarding the mechanism of C-type inactivation focusing on the hydrogen bonds near the selectivity filter.
