Sentence examples for bond of the substrate from inspiring English sources

If the hydrogen bond of the substrate carboxylate to S416 or S419 is also abolished in double mutants, Km further increases to about 1000-fold over the wild-type level (Fig. 4a).

Phenazine and its derivatives have been widely applied as nucleic acid cleavage agents due to active oxygen activating the C H bond of the substrate.

In contrast, structures that retain the functionality, and scissile bond of the substrate, can also act as reversible inhibitors; these are referred to here as substrate variants to distinguish them from substrate analogues.

The mechanism of action involves nucleophilic attack by Cys145 present in the active site on the carbonyl carbon of the scissile amide bond of the substrate and the intermediate product is stabilized by hydrogen bonds with the residues of the oxyanion hole.

Initially, the catalytic serine performs a nucleophilic attack on the peptide bond of the substrate (Figure 5).

(C ) Stereoscopic image showing all the protein side chains within 6 Å of the susceptible bond of the substrate.

The energy profile suggests that the molecule may slide along the graphene sheet with its hexagonal face parallel to the surface following the structure defined by the valent bonds of the substrate.

The class II terpene cyclases, in contrast, possess a DXDD motif, which serves as the catalytic acid that protonates the terminal carbon carbon double-bond of the substrate.

This intermediate complex is stabilized through hydrogen bonds of the substrate with two conserved glycines of GGT, commonly known as "oxyanione hole residues".

Protein disulfide bond isomerases, such as DsbC of Escherichia coli, can recognize mis-oxidized proteins and shuffle the disulfide bonds of the substrate protein into their native folded state.

Cobalt II) ion was inserted into the porphyrin ring with a yield of complex bonded to the substrate surface of 59.4 μ mol g−1.