Your English writing platform
Discover LudwigExact(1)
The Thr hydroxyl moiety sterically and electronically compensates for the loss of the hydrogen bond contributed by Asn346 in wild-type PylRS.
Similar(59)
Denaturation studies have suggested that disulfide bond contributes significantly to the stability of the SH2 domain.
Assuming that a hydrogen bond contributes 2 RT (~5 kJ/mol) free energy, the 5 RT reduction in ∆G ‡ is equivalent to 2 3 hydrogen bonds.
Denaturation studies have shown that disulfide bond contributes significantly to the stability of SH2 domain, and crystal structures of the oxidized and C122S mutant showed minor conformational changes.
DSC measurements showed that the Tm values of FabΔSS were approximately 5 °C lower than those of wild-type Fab, suggesting that the interchain disulfide bond contributes to conformational thermostability.
Both pairs of Se atoms at the edges of the As As bond contribute fully to free-volume void, since their BFSA are directed to one hemisphere without any restrictions on opposite directionality of Se atoms like in AsSe3/2 units (see Fig. 5).
Therefore it is unlikely that this single water-mediated hydrogen bond contributes significantly to potency.
Within this framework, the Tyr75 Oη···His83 Nδ hydrogen bond contributes to the hemin loading process by positioning the Oη of Tyr to coordinate the heme iron.
Although overall the cellular phenotype was not as strong as for the Mwk mutation, this result supports the suggestion that the loss of a critical hydrogen bond contributes to the Mwk gain-of-function phenotype.
To the extent that axial water "competes" for heme ligation with these drugs, the energy of the water-iron bond contributes to the apparent binding affinity of the drug.
(Another favorite holding, airline bonds, contributed to the decline).
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com