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Vemurafenib was discontinued, and therapy with ipilimumab (3 mg/kg body weight) was started.
Treatment with TT-232 (0.2 – 1.5 mg kg−1 body weight) was started on day 31 after thymectomy.
In July 2001, systemic acitretin at 0.5 mg/kg body weight was started, but stopped within 6 weeks due to elevated serum lipids.
Control mice received only the solvent in aliquots of 0.2 ml s.c. Treatment with TT-232 (1 mg kg−1 body weight) was started on day 31 after thymectomy.
A primed infusion of d-[6,6-d2]glucose (3.6 mg/kg body weight × [fasting plasma glucose/90]) followed by a continuous infusion (0.036 mg/min × kg body weight) was started to determine EGP (15).
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Systemic steroids (1 1.5 mg/kg body weight) were started in cases with severe bilateral disease and/or in cases with decrease visual acuity due to vitreous opacities.
BrdU (100 μg/g body weight) was injected daily starting the day after implantation/surgery.
In irradiated mice, body weight was significantly decreased starting day 14 with an approximate rate of −0.27 g/day and reached a nadir at day 22 with approximately 18.5% body-weight reduction.
Three days before the first CCl4 injection, once-daily treatment with FZHY powder 4.0 g (crude drug /kg or NAC 0.1 g/kg body weight respectively was started and mice were followed as noted in Figure 1.
Directly after the induction of anesthesia, the continuous infusion of 0.15 mmol/kg body weight/h was started and continued until 2 pm on the first postoperative day.
Directly after the induction of anesthesia, a continuous IV infusion of 0.15 mmol/kg body weight/h was started and continued until 2 pm on the first postoperative day, modified from the procedure reported in the pilot study of Haase and colleagues [ 12].
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