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Dynamic contrast-enhanced MRI was carried out first, during which gadopentetate dimeglumine (formerly known as Gd-DTPA; Schering Health Care, Burgess Hill, UK) was injected as a bolus at a dose of 0.1 mmol kg−1 body weight, using a two-dimensional, T1-weighted multislice, fast RF spoiled gradient echo (FSPGR) sequence.
Diets were individually limit-fed to 2.65% of body weight using a Calan gate feeding system.
Whole-body PET/CT was performed at 60 min post-injection of ~400 MBq FDG (not adjusted for body weight) using a Siemens Biograph 64-slice PET/CT scanner (Erlangen, Germany) with immediate non-enhanced CT scanning (120 Kvp/50 mA Care dose 4D; slice 5 mm; pitch 0.8; rotational speed 0.5/s) for attenuation purposes only.
He pointed to copious evidence supporting a widely available regimen known as the Diabetes Prevention Program: When people at risk for diabetes lose 5%to10%0% of their body weight using a program that reduces calorie and fat consumption and boosts their exercise, they drive down the likelihood of developing diabetes over the next five years by close to 60%.
Nonesterified fatty acids were determined using a diagnostic reagent kit (Wako Chemical USA, Richmond, VA) and triglycerides were determined using a trinder kit (Sigma Diagnostics, St Louis, MO). 10 to 16 week old male mice were injected intraperitoneally with 2.0 mg glucose per gram of body weight using a 20% (w/v) glucose solution (in 0.9% NaCl solution).
Briefly, mice were anesthetized, tracheostomized and ventilated with 6 ml/kg body weight using a pressure-controlled ventilator.
Similar(44)
Because acceptable intake of contaminants is calculated as a fraction of body weight, using an inflated assumption in a risk assessment is systematically underprotective of the entire population that weighs below the level used in the calculation.
Determining the level of body weight using an age-differentiated BMI percentile chart without more accurate knowledge of body composition or current biological age of the children might complicate data interpretation for borderline individuals.
The height of children was measured to the nearest mm using a stadimeter (Shorr Productions, Olney, Maryland, USA), and body weight using an electronic scale (Model BWB-627-A, Tanita Corporation, Japan).
The significance of the difference between full-nut dose and muffins in HbA1c remained after adjustment for duration of diabetes or body weight using an ANCOVA model (P = 0.023 and P = 0.004, respectively).
Animals were anesthetized with 5 μl per grams of body weight using an anesthetic cocktail of Ketolar (ketamine hydrochloride at 50 mg/ml) (Parke-Davis, S.L.; Barcelona, Spain) and Rompún (xylazine at 2% administered at 2.5 mg/ml; Bayer Health Care, AG, Germany) in saline solution.
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