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In hypoxic tissue, PAFR protein expression was also up-regulated, but was reduced in the bilobalide (10 mg/kg of body weight) treated group.
E. crassipes leaf aqueous extract (at 400 mg/kg body weight) treated group showed decrease in MDA content (0.12 nM/g Hb).
E. crassipes leaf aqueous extract (at 400 mg/kg body weight) treated group showed increase in total antioxidant capacity of plasma (8.96 μmol Fe (II)/L plasma) content in Wistar rats.
Dose dependant suppression of antibody response to collagen type II was also observed in Plumbagin treated groups (3.33, 6.66 and 13.33 mg/kg) with the comparison of Indomethacin (3 mg/kg body weight) treated group as shown in the Figure 3.
According to the behavioral phenotype, we selected 5-month-old 5XFAD mice, which had shown deficits in learning and memory, to assess the therapeutic effects of triptolide (20 μg/kg of body weight, treated for 8 weeks) on the symptomatic AD model.
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Human subjects were injected intravenously with endotoxin (CC-RE, lot 2) at a dose of 2-ng/kg body weight (endotoxin treated subjects) or 0.9% sodium chloride (placebo treated subjects).
Daily administration ranged from 3 to 4 mg during the treatment period to account for body weight; all treated and non-treated swine gained approximately the same amount of weight per week.
The reason behind the loss of body weight after treated with STZ was STZ reduces the number and size of adipocytes.
Injection dose of GO at 0.1 and 0.25 mg per mouse did not cause mortality of exposed mice, and showed no obvious clinical toxic signs, and the body weight of treated mice accordingly increased with the raise time increasing.
Mice on a high-fat diet gained significantly less body weight when treated weekly with 1 mg/kg CocH3-Fc(M3) compared to control mice, though their food intake was similar.
The adjusted body weight between treated and controls were similar for Karpas422 and LM1 animals (Figure 5C).
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