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Total RNAs were obtained from the epididymides of adult mice that were sham operated, castrated, or castrated but given an injection of 5 µg/g body weight of testosterone propionate everyday for 7 days from the seventh day after castration.
Castrated mice treated with 20 μg per g of body weight of testosterone developed a number and volume of tumours intermediate between the other groups.
Plasma testosterone levels were 398±95 pg ml−1 (mean±95% confidence interval) in control mice, 6±6 pg ml−1 in castrated mice, 362±64 in mice treated with 50 μg per g of body weight of testosterone and 178±59 pg ml−1 in mice treated with 20 μg per g of body weight of testosterone.
There was a significant difference in levels between castrated mice and mice treated with 20 μg per g of body weight of testosterone compared with control mice (P<0.05), but there was no significant difference between mice treated with 50 μg per g of body weight of testosterone and control mice.
We found that treatment with 50 μg per g of body weight of testosterone resulted in a significant increase in the number of tumours that formed, close to that of uncastrated mice.
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A smaller cohort of six Apc1638N mice that underwent orchidectomy, were treated with 20 μg per g of body weight of Depo-testosterone.
However, the altered hormonal environment (elevated estradiol and testosterone; see Table 1) as well as the increased body weight of the αERKO mouse should also be considered when interpreting this phenotype.
Mean body weights and testis weight compared to body weights (g/100 g body weight) of diabetic rats found significantly decreased.
Neither behavioral (e.g., latency to first sexual stimulation, number of sexual stimulations) nor physiological measures (e.g., body weight, urinary testosterone levels) of male rats predicted their reproductive success.
With testosterone replacement, the body weights of CMT pigs increased and were similar to the body weights of pigs in the IM group.
Cell-specific AR deletion did not alter body weight, circulating testosterone levels or seminal vesicle weight, but caused limited alterations in arterial contractility and blood pressure.
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