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Body weight at initial time of the study was similar in all groups.
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The mean body weight gain in each group was obtained from the difference in values between the final body weight (at P71) and the initial body weight (at P28).
Nearly 40% of severely obese ILI participants lost ≥10% of initial body weight at 1 year.
In addition, 53% achieved a clinically significant weight loss of at least 5% of initial body weight at 3 months and 48% at 6 months.
Additionally, only 7% of the maintenance intervention group had a weight loss of ≥ 5% of initial body weight at the 1-year end point [ 11].
Study participants with a BMI >40 kg/m lost ∼10% of their initial body weight at 1 year and experienced favorable changes in CVD risk factors.
No weight loss was observed in DSS-treated St2 /– mice whereas DSS-treated WT mice had significant progressive weight loss over time; up to 16% of their initial body weight at day 7 of exposure to DSS (figure 4A).
A majority (86 of 149) of participants in the weight loss program maintained at least a 5% loss of initial body weight at study end compared with less than one-quarter (18 of 76) of UC participants (P < 0.001).
Participants in IBI compared with IDEA were also more likely to achieve a clinically significant weight loss of 5% of initial body weight at 3 months (53.3 vs. 9.1%) and 6 months (48.1 vs. 15.6%) (P < 0.001) and reported more frequent use of weight control related strategies.
Food was provided after the task to maintain the animals' body weight at no less than 85% of the initial level.
The low rearing density and the strategy used to reduce the initial variation in body weight at tagging between families in the same tank may have reduced competition between individuals.
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