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For females, the NOAEL was listed as 1.6 mg PFOA/kg BW/day since higher dosages led to reduced body weight and changes in blood values [15].
To better understand the hypothalamic contribution of estrogen signaling, we first characterized some behavioral aspects of the whole-body ERα knockout mouse, and found that they had decreased homecage locomotor activity and voluntary wheel running activity, increased body weight, and changes in fat distribution to favor development of the metabolic syndrome.
However, this can be explained by normal fluctuations in the body weight, and changes in activity patterns during the study.
selenium NMs (105 130 nm, TEM; no characterization of prepared test substance) caused lower body weight and changes in hematological parameters and clinical chemistry (Shakibaie et al. 2013).
Improvement in glycaemic control and insulin sensitivity, reduction in BP, increase in body weight and changes in lipid profile were observed with pioglitazone treatment.
Our correlation of the changes in body weight and changes in low-density lean tissue of the erector spinae, psoas, and lateral and rectus abdominal muscles suggests that greater WL is associated with the loss of intramuscular fat.
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There was a moderate correlation between change in body weight and change in ALT (regression coefficient=0.38).
This framework leads to loss of body weight and change in BC components, including the bones.
We pooled data using a random effects model for two outcomes: change in body weight and change in energy intake.
Exploratory endpoints include the proportion of patients with >5% reduction in body weight and change in waist circumference.
A funnel plot was used to look for publication bias using the outcomes of change in body weight and change in energy intake.
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