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Omphalocele is a severe body wall defect that results in an abnormally large umbilical ring usually exposing the gut and liver [29], [30].
Recently, a novel bioresorbable silk mesh (SERI® Surgical Scaffold; Allergan Medical, Boston, MA) was evaluated in a rodent abdominal body wall defect model.
The ventral body wall defect called omphalocele is also associated with cardiac and anorectal malformations in more than 50% of cases.
Based on the promising results of the rodent abdominal body wall defect study, we aimed to evaluate silk mesh for use in a large ventral body wall defect in a large horse with the hypothesis that silk mesh would minimize postoperative complications and provide adequate biomechanical properties during healing.
Similar(56)
In the chick embryo, the administration of cadmium (Cd) induces ventral body wall defects (VBWDs) similar to the human omphalocele.
Full-thickness body wall defects measuring 8 × 12 cm were surgically created and then repaired with a multilaminate eight-layer form of SIS in 40 dogs.
Congenital body wall defects due to Mab21l2 mutation have been reported.
We previously reported several mutants with body wall defects associated with abdominal muscle and pelvic girdle abnormalities.
In the late fetal stages, Alx4 Lst/Lst mutants displayed pelvic girdle abnormalities and ventral body wall defects such as omphalocele, thin body wall and bladder wall hypoplasia.
An earlier version of this silk mesh was evaluated for repair of body wall defects in rodents in comparison to the conventionally used polyester meshes [ 8].
Mice deficient in Tfap2a exhibited severe ventral body wall defects (Brewer and Williams, 2004b) and had elevated expression levels of EGF receptor in the epidermis (Wang et al., 2006).
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