Definitions of excretor phenotype as described by respective authors (expressed as percentage per 1.73 m2 body-surface area, where possible).
Each parameter was indexed for body surface area, when appropriate.
Measurements were indexed to body surface area when appropriate.
Insensible water loss was calculated with the formula of Dubois, where body surface area = 71.84 × (body weight in kilograms) 0.425 × (height in centimetres) 0.725.
Where dosage calculations required body surface area or weight, 1.7 m or 70 kg per patient, respectively, was assumed.
Estimating the body surface area of a bird in the perching position only, where the area of the extended wings and tail is excluded, will highly underestimate the bird's surface area.
Where appropriate, cardiovascular variables were indexed to body surface area.
The body surface area of the piglets was calculated as K/weight (in kg)2/3, where K = 0.112 for pigs.
LVSWI was calculated by the formula SVI × (MAP – PAOP) × 0.0136, where SVI denotes SV index (SV divided by body surface area).
Initial doses were based on body weight or body surface area, with therapeutic drug monitoring approaches used to achieve target carboplatin AUC values where required.
Body surface area (BSA) was calculated by the following formula: BSA=(0.0001)× 71.84)×(weight)0.425× height 0.725, where weight was measured in kilograms and height in centimetres.
