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Thermal injury over 20% of the body surface area may lead to conditions similar to SIRS, as in septic shock.
These data suggest strongly that body surface area may not adequately correct the ventilatory response for body size in young children.
After contact with the human body, chemicals not only produce immediate harm through inflammatory response, but they also cause progressive damage leading to epidermal and dermal lesions [ 15] and major burns affecting a significant body surface area may lead to compromise of the circulation and air exchange, fluid and electrolyte imbalance and systemic shock and sepsis [ 16].
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However, over the past years it has become clear that z-scores, adjusted for body-surface area, may be a better indicator of any serious enlargement [9, 10].
Patients with between 10 and 30% body surface area involvement may be considered 'overlap TEN/SJS' [ 6] and, if these were recorded solely as SJS within our data, then the SCORTEN for these patients would be incorrect.
The maximum dose should not exceed 120 mg/m2 body surface area, and renal dysfunction may require a dosage reduction.
Analyzing these data with arterial internal diameter normalized for body surface area as a continuous variable may have yielded more robust results.
Normalisation to body surface area or lean body mass may be advantageous.
In obese cancer patients, it is believed that fixed drug dosing or dose "capping" (i.e., limiting the body surface area to a pre-specified maximum number) may result in inadequate drug delivery [ 22].
The SA variation in this assessment was limited; however, because the SA was replaced with body surface area (assuming bathing every day), this assessment may be expected to produce an overestimated risk.
Moreover, a patient may have mild disease on the basis of body surface area (BSA) involvement, but localization of lesions in vulnerable areas (e.g., the face, feet, hands, and/or genitals) may warrant systemic therapy.
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