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Mean body surface area involvement with PsO was 14%.
Skin assessments were restricted to patients with at least 3% body surface area involvement at enrollment.
A minimum threshold of body surface area involvement is required to score a skin severity of 3 for hidebound skin changes.
Eighteen subjects with at least 3% body surface area involvement were enrolled in 4 dose groups (0.1, 0.3, 1.0, and 5.0 mg/kg).
Skin assessments were restricted to patients with at least 3% body surface area involvement (N = 128) at enrollment, as reported previously.
Patients with between 10 and 30% body surface area involvement may be considered 'overlap TEN/SJS' [ 6] and, if these were recorded solely as SJS within our data, then the SCORTEN for these patients would be incorrect.
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It is possible to define severe disease as a PASI score of >10 (or an involvement of >10% of the body surface area involved) and a DLQI score of >10 (Finlay 2005).
Previously reported data suggest that age, total body surface area (TBSA) involvement, late recognition and treatment of TEN are poor prognostic indicators.
Moreover, a patient may have mild disease on the basis of body surface area (BSA) involvement, but localization of lesions in vulnerable areas (e.g., the face, feet, hands, and/or genitals) may warrant systemic therapy.
Note that in the clinical trials, PASI scores at follow-up were reported for patients who had ≥3% body surface area (BSA) involvement at baseline or a PASI score ≥2.5 at baseline.
6 Dermatologists should formally measure the body surface area (BSA) involvement of disease (size of the patient's palm and fingers approximates 1% of BSA and can be used to assess the amount of skin disease involvement), typically using the modified Severity Weighted Assessment Tool, in which patches, plaques and tumours are multiplied by a factor of 1, 2 and 3 or 4, respectively.
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