Your English writing platform
Discover LudwigSuggestions(1)
Exact(2)
Indexing to body surface area does not remove age dependence.
Since for most anticancer agents dosing according to body surface area does not reduce the interpatient variability in PKs, it was decided to use absolute doses of XR11576 and study the relation between oral clearance of XR11576 and the body surface area (Ratain, 1998).
Similar(58)
Correction of clearance or volume of distribution for body surface area did not reduce the CV (Table 3).
Excretion values expressed as the ratio between the two, allowing for body surface area, did not differ materially from those of 100 age-matched controls.
> -wrap-foot> > In those for whom data were available, serum albumin, cholesterol, age, body mass index and body surface area did not demonstrate a significant relationship with event-free follow-up.
There was also a relationship between the observed AUC and the relative reduction ratio of platelets, although the dose of nedaplatin based on body surface area did not relate to the relative reduction ratio of platelets.
However, in an adult population there is really no reason to use surface area in determining doses, unless surface area does correlate with clearance across the range of body sizes seen in the target adult population.
After indexing for body surface area, uptake did not correlate with respiratory function parameters.
Body surface area-dosing does not account for the complex processes of cytotoxic drug elimination.
In order to calculate SCORTEN we assumed that patients coded as TEN had involvement of greater than 10% of body surface area and other patients did not.
Dosing was on a weight rather than body surface area basis, as is often done for drugs which primarily disperse in the intravascular space, such as liposomes and antibodies, given the well-established correlation between body weight and blood volume 13.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com