While the prevailing view is that O2 delivery is a factor that influences whole-body maximal O2 consumption, it remains to be determined if, and to what extent, the observed decrement in muscle state 3 mitochondrial O2 flux capacity in diabetic patients contributes to the lower systemic VO2max and substrate utilisation.
Secondary outcomes include HRQL, levels of depression and anxiety, lung function, daily life physical activity, body composition, maximal aerobic capacity, strength muscle and sleep disorders.
These are used to calculate two values - the body's maximal oxygen uptake and the point at which anaerobic metabolism exceeds aerobic metabolism (anaerobic threshold).
Oral glucose tolerance, blood glycated haemoglobin, lipid profile, body composition, maximal workload capacity, whole body and skeletal muscle oxidative capacity and skeletal muscle fibre type composition were assessed before and after 2 and 6 months of intervention.
An oral glucose-tolerance test was then performed with the administration of 1.75 g of glucose per kilogram of body weight (maximal dose, 75 g) followed by measure of insulin and glucose two hours after glucose ingestion.
Using a radioimmunoanalysis method, glucose and insulin levels were determined while fasting, and 2 hours after the administration of an oral load of 1. 75 g of hydric glucose per kg of body weight, (maximal dose of 75 g).
Bernard et al. performed a randomized, double-blind, placebo-controlled trial of IV ibuprofen (10 mg per kilogram of body weight (maximal dose, 800 mg), given every six hours for eight doses) in 455 patients who had sepsis, defined as fever, tachycardia, tachypnea, and acute failure of at least one organ system [ 5].
Outcome measures were feasibility (taking into account continuation of the exercise program and/or occurrence of complications related to the WBV) and improvement in functional performance due to the intervention (taking into account balance and gait, upper limb and lower body flexibility, maximal grip strength and closed chain bilateral leg extension).
ECMO entry criteria at our hospital include: weight greater than 2 kg body weight, maximal medical therapy consisting of a high fraction of inspired oxygen, and high pressure settings on the respirator, as well as an oxygenation index greater than 40.
