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Active muscle and whole body lactate kinetics after endurance training in men.
Muscle lactate production and total body lactate clearance remained constant.
57 Disturbances in whole body lactate turnover appear to contribute to the development of insulin resistance.
Regardless of the mechanism s), the increased whole body lactate efflux in peritonitis was mainly due to increased extrasplanchnic lactate production.
We now show that the same process occurs in the heart, an organ with high metabolic demands and accounting for only a small amount of total body lactate production.
Whole body lactate production increases with age (Wallace, 2005) and loss of cavin-3 may exasperate lactate production to a point after which fatty acid demand for gluconeogenesis triggers lipolysis of triglycerides stored in adipose tissue.
Similar(54)
Summermatter S, Santos G, Perez-Schindler J, Handschin C. Skeletal muscle PGC-1alpha controls whole-body lactate homeostasis through estrogen-related receptor alpha-dependent activation of LDH B and repression of LDH A.
The model is concordant with previous observations regarding hepatic GCK activity and whole-body lactate metabolism.
However, if this was the case, it would not increase the net lactate efflux from muscle and therefore it would not participate in whole-body lactate production as measured in the present experiments.
We believe this novel model of lactate metabolism will give new insight into the influence of genetic alterations of GCK and GCKR in vivo and extend the usability of the FSIGT protocol by providing specific information about the status of hepatic glucose homeostasis, including estimates of hepatic lactate production and whole-body lactate clearance.
Weaning involves a fuel shift from ketone bodies, lactate and glucose in immature mammals to glucose in adult brain.
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